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differential hematology management systemic classification disease erythematosus evaluation gap globulin hivaids hodgkins igg4 infections lupus lymphoma myopathy myositis oncology phenotypes
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
failure, COPD, Lung ... Evaluation: Imaging (CXR ... +/- High res CT ... Infectious Diseases ... #diagnosis #evaluation
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... biliary, renal, lung ... concentration PET-CT ... #phenotypes #workup ... #treatment #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... (interstitial lung ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Immunosuppression • Autoimmune ... Hodgkin Lymphoma Workup ... Mediastinal mass) • CT ... number of sites of disease ... physical exam, CT
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... , pancreas, stomach ... , pancreas, stomach ... : • PBC, autoimmune ... Myositis #Myopathy #rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Cirrhosis, ETOH, autoimmune ... ovarian tumors, lung ... #differential #diagnosis ... #hematology
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