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diagnosis differential rheumatology management dermatomyositis algorithm antimda5dm antinxp2 antinxp2dm autoimmune common compared comparison cvid erythemas gap globulin hypogammaglobulinemia igg4 immunodeficiency
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... anti-NXP2 Abs Lung ... Mechanic's hands #AntiMDA5DM ... #AntiMDA5 #Dermatomyositis ... dermatology #diagnosis
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... biliary, renal, lung ... concentration PET-CT ... IgG4 #Related #Disease ... management #phenotypes #workup
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status NTM Cause ... disease, volume ... disease ... Hematologic malignancy ... Imaging, high res CT
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • ... Granulomatous disease ... • Liver diseases ... disease (GLILD) ... hypogammaglobulinemia #immunology #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Better call hematology ... , this list is long ... can drive this disease ... As with many disease ... #hematology
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
early localized disease ... cancers, including lung ... called "Bazin's disease ... so-called fifth disease ... differential #diagnosis #dermatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
disease Malignancy ... disease • Dysphagia ... disease • Myositis ... skeletal muscle disease ... myocarditis Other Diseases
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
• Heavy chain disease ... plasmacytoma • Castleman disease ... Sarcoidosis) • Liver disease ... gastric tumors • Hematology ... differential #diagnosis #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Muscle atrophy may cause ... had more severe disease ... Non-small-cell lung ... Dermatomyositis: • ILD ... #dermatology
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