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diagnosis rheumatology autoimmune cardiology cardiotoxicity chemotherapy common cvid differential disease gca giantcell her2 hypogammaglobulinemia igg4 immunodeficiency immunology myopathy myositis pharmacology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... head and neck, pancreas ... biliary, renal, lung ... concentration PET-CT ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung ... lymphocytic interstitial lung ... Chest CT: • Ground-glass ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
in literature (NEJM ... identifies 85 to 95% of cases ... (Cornelia NEJM ... day, followed by long ... Symptoms #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Arthralgia and Arthritis ... MALT Lymphoma • Lung ... #Diagnosis #Management
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Diagnosis and Management ... of unknown cause ... for giant cell arteritis ... subacromial-subdeltoid bursitis and long ... #Rheumatology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
Management of Anthracyclines ... cause cardiomyopathy ... HER2 agents cause ... of therapy • Long-term ... Cardiotoxicity #cardiology #oncology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
, pancreas, stomach ... , pancreas, stomach ... • Nonerosive arthritis ... statins - probably caused ... Myositis #Myopathy #rheumatology
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