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differential rheumatology ana causes abnormal aptt coagulation patterns prolonged pt activation algorithm anca anemia antibody antineutrophil arterial arthritis autoantibodies disease
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
disease (MCTD), Drug-induced ... Kumfer @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology ... #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antineutrophil cytoplasmic antibodies ... Systemic lupus erythematosus ... Anti-histone (in drug-induced ... #diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Kumfer @AnnKumfer #Antinuclear ... #patterns #rheumatology ... #diagnosis #differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Blood Smear • Drugs ... B12 - Anti-IF Antibodies ... B12 - Anti-IF Antibodies ... Algorithm #Causes #Hematology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... SLE (60-70%) & drug-induced ... Lupusreference #Antinuclear ... Systemic #lupus #erythematosus ... #diagnosis #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... Reduced liver synthesis ... Prolonged #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Drugs: Direct or ... antiphospholipid antibodies ... • Reduced liver ... #differential #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
- Differential Diagnosis ... • Intravenous Drug ... Syndrome, Ischemic Liver ... Antiphospholipid antibodies ... pathophysiology #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Systemic lupus erythematosus ... ) • Sepsis • Drug-induced ... thrombocytopenia • Liver ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Systemic lupus erythematosus ... (SLE) - Antinuclear ... double-stranded DNA antibodies ... profile, including liver ... (to support a diagnosis
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