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diagnosis oncology leukemia lymphocytic classification cold cvid globulin hemeonc hemolytic hodgkins immunodeficiency immunology mds myelodysplasia myelodysplastic polycythemia protein proteingap syndromes
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... Orange or Hep C Clinical ... cells can indicate disease ... • Neutropenia, anemia ... #oncology #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... symptoms - most common ... younger pts) Differential ... #anemia #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... autoimmune hemolytic anemia ... DDX - Other causes ... #immunology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... - infiltrates (anemia ... Agranulocytosis • Hypogammaglobulinemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... lymphoma (Richter ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... hemeonc #diagnosis #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
- Clinical Presentation ... Workup: • Full ... number of sites of disease ... classification #hematology ... #oncology #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... Marrow Failure • Chronic ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Diagnosis Algorithm ... Better call hematology ... normal/high - Chronic ... , think about common ... #workup #hematology
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