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oncology causes management algorithm chronic hemolytic leukemia lymphocytic workup bandemia cold common cvid elevatedmcv enzymes erythematosus extravascular gap globulin hemeonc
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Secondary Cold ... Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... #anemia #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Small Bowel Disorder ... Myelodysplastic Syndromes ... • Rule out B12 and ... Deficiency - Abnormal ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... pylori test (GI symptoms ... anti-phospholipid antibodies ... changes), high MCV anemia ... #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... . primary cold agglutin ... disorders, Mycoplasma ... Extravascular #Causes #differential ... #diagnosis #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Clinically significant ... - nucleus looked ... • Autoimmune diseases ... #WBC #CBC #hematology ... #pathophysiology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... immunophenotype Clinical ... Vmphocytosis on routine CBC ... 3) Monoclonal antibodies ... Leukemia #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Diagnosis: • ANCA-associated ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... DDX: Rule Out Secondary ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
symptoms/signs ... box indicates all ... presence of metabolic syndrome ... body mass index; FBC ... Liver #Enzymes #Differential
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