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diagnosis oncology workup agglutinin algorithm bandemia chronic cll cold elevatedmcv erythematosus gap globulin hemolytic hodgkins lupus lymphocytic lymphoma macrocytic macrocytosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Deficiency - Abnormal ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... decreased PLT count: CBC ... pylori test (GI symptoms ... changes), high MCV anemia ... #Workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Secondary Cold ... Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... #hematology #diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Clinically significant ... Tissue damage • Leukemia ... • Autoimmune diseases ... #CBC #hematology ... #pathophysiology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... workup #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... leukemia • Lung ... Erythematosus #Diagnosis #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... DDX: Rule Out Secondary ... Causes • Anemia ... Myeloproliferative Disease ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... Connective tissue disorders ... gastric tumors • Hematology ... Gap #ProteinGap #differential ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma - Clinical ... ingestion • B symptoms ... number of sites of disease ... #hematology #oncology
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