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diagnosis management chronic cll lymphocytic agglutinin algorithm aplastic bandemia causes cold elevatedmcv erythematosus hemeonc hemolytic hodgkins lupus lymphoma macrocytic macrocytosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Small Bowel Disorder ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... Deficiency - Abnormal ... Algorithm #Causes #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... DDX: Rule Out Secondary ... Myeloproliferative Disease ... blood count with differential ... #hematology #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Secondary Cold ... Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
in adults • Disorder ... immunophenotype Clinical ... Vmphocytosis on routine CBC ... 3) Monoclonal antibodies ... #oncology #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Clinically significant ... Tissue damage • Leukemia ... • Autoimmune diseases ... #CBC #hematology ... #pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... • Hypocellular myelodysplastic ... virus (EBV) • Leukemia ... • Improve the symptoms ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... leukemia • Lung ... Erythematosus #Diagnosis #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma - Clinical ... ingestion • B symptoms ... number of sites of disease ... #hematology #oncology
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