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diagnosis oncology agglutinin chronic classification cll cold common cvid erythematosus gap globulin hypogammaglobulinemia immunodeficiency immunology leukemia lupus lymphocytic protein proteingap
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... - Clinical Presentation ... ingestion • B symptoms ... Lymphoma Workup ... classification #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... Viral Infection Clinical ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #oncology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Induced Lupus: • Symptoms ... titers > 1:80 • CBC ... cyclophosphamide) • Hodgkin ... lymphoma and leukemia
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... infection risk secondary ... to 8 years Clinical ... anemia) • Systemic ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... abnormal free light ... #diagnosis #hematology
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