1946 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
FOR TESTING: • Peripheral ... symptoms (eg, skin ... Differential #diagnosis #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... vasculitis • Hematologic ... criteria for 1) hematologic ... cells including peripheral ... Autoinflammatory #Somatic #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... neuropathy • Peripheral ... amyloidosis, PAH Skin ... : • Dry skin (xerosis ... Nephrogenic DI Hematologic
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blasts in the peripheral ... maturation • (Peripheral ... • ↓Hg & PLT • Peripheral ... CLL -> Invade Skin ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cytometry • Peripheral ... workup #oncology #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Headaches • Pale skin ... anemia) Labs: • Peripheral ... Anemia #oncology #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Malignancy (e.g. hematologic ... Mononeuritis Multiplex • Peripheral ... Seizures • Strokes Skin ... vein thrombosis Hematologic
Central Distribution, Febrile / Ill:
 - Viral Exanthem 
 - Lyme Disease (erythema migrans) 
Central Distribution,
herald patch) Peripheral ... Erythema multiforme Peripheral ... - Eczema Peripheral ... Algorithm #Diagnosis #Dermatology ... #Skin
Dermatomes and Peripheral Nerves - Segmental Innervation of the Skin and the Peripheral Nerve Supply (Anterior
Dermatomes and Peripheral ... Innervation of the Skin ... and the Peripheral ... #Dermatomes #Peripheral ... #Innervation #Skin
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
bone marrow and peripheral ... just beneath the skin ... leukopenia) Peripheral ... differential • Peripheral ... Syndromes #diagnosis #hematology