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diagnosis differential oncology erythematosus leukemia lupus signs symptoms systemic activation algorithm arthritis autoantibodies causes chronic cll disease disorders hemolytic laboratory
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... genotypes): SS, SC, SE ... Schistocytes, thrombocytopenia ... Diagnosis #Algorithm #workup ... #hematology #testing
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Photosensitivity, Butterfly rash ... ) Blood (75%): Anemia ... Leucopenia/lymphopenia, Thrombocytopenia ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... Neurological 12% - Thrombocytopenia ... - Hemolytic anemia ... Lupusreference #SLE ... #differential #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... - CCP antibody testing ... the presence of anemia ... Arthritis #laboratory #workup ... #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... with leukopenia, anemia ... , and thrombocytopenia ... Diagnosis #Management #Hematology ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... • Neutropenia, anemia ... , thrombocytopenia ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... Workup: • Complete ... Syndromes #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Granulocytic cells in all phases ... - infiltrates (anemia ... , thrombocytopenia ... lymphocytic lymphoma (SLL ... #Leukemia #Hematology
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