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Adrenal Insufficiency - Differential Diagnosis Workup Algorithm Primary Adrenal Insufficiency: • Autoimmune primary adrenal insufficiency • Adrenoleukodystrophy,
Adrenal Insufficiency ... Algorithm Primary Adrenal ... Autoimmune primary adrenal ... ACTH-deficiency • Combined pituitary ... Workup #Algorithm #endocrinology
The principal endocrine 'axes' and glands. Parathyroid glands, adrenal zona glomerulosa and endocrine pancreas are not
Parathyroid glands, adrenal ... controlled by the pituitary ... Endocrine #Axes #Endocrinology ... Pathways #Diagnosis #Pituitary
Hypercortisolism (Cushing syndrome) - Simplified Differential Diagnosis Algorithm Exogenous (ACTH-independent) Endogenous • ACTH-dependent: - ACTH-secreting
ACTH-secreting pituitary ... ACTH-independent: - Adrenal ... hyperplasia - Adrenal ... Diagnosis #Algorithm #endocrinology
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm ACTH-Dependent (Secondary): • Pituitary Dysfunction • Hypothalamic Dysfunction ACTH-Independent (Primary):
Causes of Adrenal ... Secondary): • Pituitary ... Thrombophilia (adrenal ... Medicine @SCVMCMed #Adrenal ... Algorithm #Causes #endocrinology
Primary vs Secondary Adrenal Insufficiency - Pathophysiology Primary AI = adrenal glands themselves are the problem. This
Primary vs Secondary Adrenal ... Pathophysiology Primary AI = adrenal ... Secondary AI = the pituitary ... leads to limited adrenal ... Pathophysiology #endocrinology
Cushing Syndrome Testing Algorithm INDICATIONS FOR TESTING: • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension) Testing:
Hormone • MRI of adrenal ... glands, pituitary ... diagnosis #algorithm #endocrinology ... #Adrenal #Hyperfunction
Congenital Adrenal Hyperplasia - 21-Hydroxylase Deficiency - Signs and Symptoms • Brain: Androgenization effects, Glucocorticoid effects,
Congenital Adrenal ... • Hypothalamic–Pituitary ... resistance • Adrenal ... subfertility, Adrenal ... Symptoms #diagnosis #endocrinology
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
Primary Adrenal ... dysfunctional adrenal ... hypothalamus or pituitary ... deficiency (from the pituitary ... diagnosis #testing #endocrinology
Diagnosis Adrenal Insufficiency - Algorithm Step 1) Screening Test: 6-8AM Cortisol Level - Early morning cortisol levels
Diagnosis Adrenal ... determines if the adrenal ... . problem with pituitary ... gland) #Adrenal ... #Stimulation #Endocrinology
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
Adrenal Insufficiency ... Summary Primary Adrenal ... pan-hypopituitarism including: pituitary ... @AnnKumfer #Adrenal ... Diagnosis #Management #Endocrinology
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