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betadglucan diagnosis fungal galactomannan biomarkers bloodculture endocarditis falsepositives infectiousdiseases infective laboratory testing workup
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... cultures remain negative ... antimicrobials, clinical ... whipplei, Fungi (Aspergillus ... Endocarditis #diagnosis #differential
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Coccidioides - Negative ... cut-offs defined in clinical ... Cryptococcus - Negative ... BAL GM does not differentiate ... Galactomannan #diagnosis #comparison
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
Galactomannan Testing Sensitivity ... Almost always negative ... cut-offs defined in clinical ... >90% (In most clinical ... in BAL does not differentiate
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