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diagnosis betadglucan brain causes galactomannan aspergillus biomarkers bloodculture comparison endocarditis falsepositives infective laboratory negative sensitivity testing workup
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
fastidious bacteria or fungi ... antimicrobials, clinical ... Tropheryma whipplei, Fungi ... Endocarditis #diagnosis #differential ... #workup #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... #Differential # ... Diagnosis #causes #infectiousdiseases
Concurrent Brain and Lung Lesions • Bacteria: Nocardia spp, Strep anginosus, Staph aureus, Klebsiella pneumoniae (hypervirulent),
Concurrent Brain ... ) • Fungi: Aspergillus ... #Infections #Concurrent ... #Differential # ... Diagnosis #causes #infectiousdiseases
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) ... cut-offs defined in clinical ... surfaces - Infections ... BAL GM does not differentiate ... decreased with: concurrent
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives 1,3-Beta-D-Glucan • Cell wall component of many fungi
surfaces, Albumin, Infections ... >90% (In most clinical ... in BAL does not differentiate ... Sensitivity ↓ w/concurrent ... result in + as long
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