29 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... distal tubule. ↑ Nacl ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... #nephrology #diagnosis
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... acid, Liddle's Syndrome ... #Hypokalemia # ... Diagnosis #Algorithm #nephrology ... #causes #low #potassium
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Diagnosis Algorithm Hypovolemia ... and metabolic alkalosis ... Hypovolemia, UNa ... #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... #Causes #differential ... #diagnosis #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... , Gitelman Syndrome ... aldosteronism #Metabolic #Alkalosis ... Diagnosis #Algorithm #Nephrology ... #Causes
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... wasting from other causes ... suggests extra-renal causes ... - Metabolic Alkalosis ... differential #potassium #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... the indicated causes ... urine #Algorithm #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Rhabdomyolysis Treatment ... #diagnosis #nephrology ... #management #pathophysiology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... have fever - ACS ... : • Pathophysiology ... hydration - Hyperkalemia
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
↑ ↑ Metabolic alkalosis ... (AG) = {Na - (Cl ... D-lactate (short bowel syndrome ... Acetazolamide Causes ... Diagnosis #Summary #Nephrology