15 results
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... Differential Diagnosis Algorithm ... metabolic alkalosis ... , Gitelman syndrome ... #Diagnosis #Algorithm
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... Algorithm Cl- ... , Gitelman syndrome ... #Metabolic #Alkalosis ... #nephrology #differential
Causes of Metabolic Alkalosis - Differential Diagnosis Algorithm
Urine chloride < 20 mmol/l - Chloride responsive (Chloride
Causes of Metabolic ... Alkalosis - Differential ... Diagnosis Algorithm ... , Gitelman's Syndrome ... #Alkalosis #Causes
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... Diagnosis Algorithm ... , Gitelman Syndrome ... #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... → Hypokalemia Metabolic ... alkalosis - ... #nephrology #diagnosis
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... Diagnosis Algorithm ... , Gitelman Syndrome ... #Nephrology #Causes
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Differential Diagnosis Algorithm ... alkalosis - Fistulas ... - Bartter - Gitelman ... Pathophysiology #Nephrology ... #Chloride
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... furosemide-like lesion) • Gitelman ... thiazide-sensitive site) Metabolic ... after fasting #Metabolic ... Diagnosis #Causes #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... hypomagnesemia • Metabolic ... alkalosis • Normal ... Hypochloremic metabolic ... #nephrology #management
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
Alkalosis Urine ... Contraction Urine Cl ... Barter, or Gitelman ... Syndrome Unremarkable ... #alkalosis #algorithm