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Cryptogenic Organizing Pneumonia (COP)

Cryptogenic Organizing Pneumonia Overview:
 • Idiopathic form of organizing pneumonia
 • formerly BOOP
Pneumonia - Clinical ... , cavities • HRCT ... Pneumonia - Diagnosis ... BOOP #pulmonary #ILD ... #diagnosis #management
Nodular pattern
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary TB: random nodules
3. Sarcoidosis: nodules with perilymphatic
Nodular pattern ... Hypersensitivity pneumonitis: ill ... #Clinical #Radiology ... #HRCT #CTChest ... #Comparison #Table
HRCT findings in OP
- Bilateral peripheral consolidations, sharply demarcated.
- Consolidations may be migratory.
- Lesions may show
HRCT findings in ... carcinoma, the diagnosis ... of cryptogenic organizing ... #Clinical #Radiology ... #Pneumonia #ILD
Notice that there are multiple densities in both lungs.
The larger ones are ill-defined and maybe there
dealing with the differential ... diagnosis of chronic ... of organizing pneumonia ... #Clinical #Radiology ... #Distribution #Organizing
On the left some diseases with a nodular pattern.
1. Hypersensitivity pneumonitis: ill defined centrilobular nodules.
2. Miliary
bronchiolitis: ill ... #Clinical #Diagnosis ... #Radiology #Pulmonary ... NodularPattern #Differential ... #Comparison #Table
Differential diagnosis of Langerhans cell histiocytosis.
Nodular LCH:
- Sarcoidosis: perilymphatic distribution.
- Metastases: random distribution.
Cystic LCH:
- LAM: round
Differential diagnosis ... Nodular LCH: - Sarcoidosis ... central dot. - LIP #Clinical ... #Diagnosis #Radiology ... #Comparison #Table
UIP with honeycombing (left) and chronic HP (right)
Differential diagnosis of Hypersensitivity Pneumonitis.
Subacute stage:
- RB-ILD: seen in
chronic HP (right) Differential ... show very similar HRCT ... #Clinical #Diagnosis ... #Radiology #CTChest ... #UIP #Comparison
On the left a smoker with RB-ILD with subtle HRCT-findings.
The dominant pattern is ground glass opacification.
Additional
with subtle HRCT-findings ... there is a broad differential ... diagnosis and additional ... clinical information ... #Clinical #Radiology
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
cut-offs defined in clinical ... BAL GM does not differentiate ... setting of GVHD) ID ... Galactomannan #diagnosis ... #comparison