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diagnosis hematology blood classification differential management reactions algorithm cryofibrinogenemia cryoglobulins glomerulonephritis progressive rapidly rpgn transfusion transfusions types vasculitides
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
causing endothelial injury ... • They can cause ... Cryoglobulins Cause ... (e.g. systemic lupus ... classification #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... Post-strep GN, Lupus ... Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... diagnosis #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
of fibrin split products ... • Fibrin split products ... malignancies, vasculitis ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... Related Acute Lung Injury ... TRALI): Leading cause ... more likely to cause ... tested include: Malaria
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... Related Acute Lung Injury ... TRALI): Leading cause ... tested include: Malaria ... diagnosis #management #hematology
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