7 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... • Infections: Malaria ... #hematology #anemia
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... suspected, consider malaria ... #Algorithm #workup ... #hematology #testing
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... #Rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Workup: • Complete ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Albumin > 4) Work-up ... gammopathy, and skin ... gastric tumors • Hematology ... anemia • Other ... #hematology