22 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Manifestations: Malar ... of SLE versus DIL ... life-threatening • Treatment ... #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Manifestations: Malar ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
permeability Diagnosis ... Puncture, EEG Treatment ... CNS #neurology #rheumatology ... #cerebritis #diagnosis ... #management #treatment
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation (DIC ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
& NPSLE rare, Malar ... constitutional symptoms • Treatment ... #DIL #rheumatology ... #diagnosis #treatment ... #management
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... severe disease Treatment ... #SLE #Summary #diagnosis ... #rheumatology # ... management
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Leishmaniosis, malaria ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
SJIA], systemic lupus ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... MAS, Visceral, DIC ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
IL-6, TNF-a, ? ... synovitis (40%) Treatment ... Disease #AOSD #rheumatology ... #diagnosis #management ... #treatment