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diagnosis management differential causes treatment medications table nephrology hematology cardiology comparison peds workup ddxof endocrinology gastroenterology pulmonary criticalcare antibiotics dosing
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... • Absence of platelet
Summary of characteristics of Platelet Aggregation Inhibitors #AntiPlatelet #Inhibitors #Pharmacology #Table #Overview #Interactions #Pharmacology #Cardiology
characteristics of Platelet ... AntiPlatelet #Inhibitors #Pharmacology ... #Interactions #Pharmacology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
Platelet disorders ... ristocetin • Normal platelet ... count and platelet ... • Platelet flow ... Usually normal platelet
Inhibitors of Platelet Aggregation #Antiplatelet #Inhibitors #Pharmacolgy #Pathophysiology #MechanismOfAction
Inhibitors of Platelet ... Antiplatelet #Inhibitors #Pharmacolgy
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
children) • Platelets ... extremely low platelet
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Differential Diagnosis Platelet ... Diagnosis #causes #Platelets
Approach to suspected Heparin-Induced Thrombocytopenia (HIT) • Suspected HIT Algorithm • "4 T's" clinical probability score:
Suspected HIT Algorithm ... Thrombocytopenia (platelet ... Timing of onset of platelet ... diagnosis #4Ts #algorithm
Mechanism of Action of Platelet Aggregation Inhibitors - COX Inhibitors - ADP Inhibitors - GP IIb/IIIa Receptor Blockers #Antiplatelet #Pharmacolgy
Mechanism of Action of Platelet ... #Antiplatelet #Pharmacolgy
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... concentrate - Platelets ... Hct < .005) Platelet ... pheresis - Platelets
Thromboelastography (TEG) based therapy and Management If r time prolonged -> FFP If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet
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