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diagnosis hematology management algorithm mds myelodysplastic syndrome arteritis associations cancers chronic classification dermatology erythematosus gap gca giantcell globulin immunology infection
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... • Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... diagnosis #workup #oncology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... • Marrow Aplasia ... Inflammation • Cancer ... #Differential #
Infection-Related Cancers Viruses: • HPV - Cervical, anogenital, head and neck, skin cancer • HTLV-1 - Adult
HTLV-1 - Adult T-cell ... Leukemia • HIV ... • EBV - NHL, Hodgkin's ... • Merkel cell ... #oncology #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... -> AML: Blast crises ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Hematology #Oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic ... Anemia • Toxic ... Leukemia, Tumour ... ITP • SLE • CLL
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Immunohistochemical studies (to differentiate ... Lymphoma Treatment ... classification #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... anemia Treatment ... #Anemia #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Anemia • Aplastic ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... blood count with differential ... diagnosis #hematology #oncology
Retroviral Infections: Mechanisms of Oncogenesis Note: A retrovirus is an RNA virus that uses reverse transcriptase to
RNA virus that uses ... retrovirus-associated cancers ... ; • HIV (Non-Hodgkin ... lymphoma/leukemia ... pathophysiology #immunology #oncology
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