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diagnosis hematology management chronic cll leukemia lymphocytic mds myelodysplastic workup anthracycline cardiotoxicity hemeonc myelodysplasia pharmacology plasmacytoma solitary syndrome syndromes toxicity
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Cytotoxic drugs/Chemotherapy ... anemia Treatment ... #Anemia #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... = funny-shaped cells ... cytopenias (usually anemia ... Allogeneic stem cell ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
and other C Cell ... • Neutropenia, anemia ... aplasia • ITP ... microglobulin Treatment ... diagnosis #workup #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
5) Symptoms of anemia ... Transformation to large cell ... benefit of immediate chemotherapy ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... marrow studies Treatment ... ) • Intensive chemotherapy ... diagnosis #hematology #oncology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Solitary Cell Plasmacytoma ... • No CRAB - no anemia ... Bone marrow Treatment ... • Surgery and chemotherapy ... #Plasmacytoma #Oncology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
) and initiate treatment ... monitoring is not well ... Cardiotoxicity #cardiology ... #oncology #pharmacology ... #toxicity #chemotherapy
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