12 results
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Pathophysiology of Diabetic ... Ketoacidosis (DKA ... Insulin is the primary ... Pathophysiology #Diabetic ... #Diabetes #Endocrinology
Diabetic Ketoacidosis 
Management Priorities
1. Fluids 
2. Insulin 
3. Potassium 
4. Acidosis 
5. Re-establish oral fluids,
Diabetic Ketoacidosis ... Identification and treatment ... underlying cause #DKA ... #Diabetic #Ketoacidosis ... #Diabetes #Management
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
produce endogenous insulin ... • Diabetic ketoacidosis ... by complete insulin ... differential #diagnosis #management ... #endocrinology
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... intracellularly: • Insulin ... excretion: • Urinary ... #Hyperkalemia #management ... #potassium #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Increased plasma insulin ... (treatment of diabetic ... thiazide-like diuretics), Primary ... hyperaldosteronism, Secondary ... differential #diagnosis #nephrology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
-> Stimulates Insulin ... mechanism helps lower primarily ... #Pharmacology #Management ... #Diabetes #DM2 ... #Endocrinology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... drips unless also diabetic ... DKA is essentially ... differential #algorithm #management ... #treatment #criticalcare
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
irrigation • Management ... • Nephrogenic diabetes ... Lithium-induced nephrogenic diabetes ... DDAVP) • Central diabetes ... Tolvaptan) • Treatment
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
transfusions), ↓insulin ... (DM, DKA, octreotide ... : • Insulin 5- ... Give D50 before insulin ... #nephrology #K
Pheochromocytoma - Diagnosis and Management Summary
10 percent rule = 10% of pheochromocytomas are extra-adrenal, multiple, bilateral,
paroxysmal HTN, most primary ... sedimentation rate, insulin ... , and, rarely, secondary ... apparent type 2 diabetes ... pheochromocytoma: primary