17 results
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... agent are the main ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... transformation to acute ... only curative treatment ... #treatment #hematology ... #oncology
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
Inflammatory Joint Pain ... - Differential ... Sicca) Syndrome ... Rheumatic Fever Acute ... Inflammatory #JointPain #MSK
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... malignancies Treatment ... Methotrexate • AIN ... #AKI #Cancer #Oncology ... #Differential #
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Leg Pain - Differential ... Bursitis • IBD • Psoriasis ... Immobilization) • Acute ... #differential # ... lower #extremity #msk
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Tumor Lysis Syndrome
An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... An acute, life-threatening ... Walid Malki, MD, MS ... #TLS #oncology ... #management #UricAcid
Pustular Skin Lesions - Differential Diagnosis Framework

What are pustules?
• Pustules < 5-10 mm + pus
• Material
Skin Lesions - Differential ... SAPHO syndrome ( ... with rheumatic pain ... Acute generalized ... #Diagnosis #Dermatology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
lesions + Rheumatic pain ... , psoriasis vulgaris ... and lower jaw Treatment ... Rheumatology #diagnosis #management ... #Dermatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... • Fever is the main ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology