10 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... , Palpable purpura ... • Palpable purpura ... Vesicles overlying purpuric ... Henoch-Schönlein purpura
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
- Differential Diagnosis ... Small Vessel: Petechiae ... , Palpable purpura ... Vasculitis: - Ig A (HSP ... Disease • Cogan syndrome
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... rash, Vasculitis, Purpura ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
Clinical suspicion ... : • Nephrotic syndrome ... • Periorbital purpura ... floaters, periorbital purpura ... arrhythmia • Palpable
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... : • Clinical triad ... of Palpable purpura ... Henoch-Schönlein purpura ... (e.g. systemic lupus
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... purpura (lower
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis: • Purpura ... Henoch Schonlein Purpura ... erythematous nodules, purpura ... purpura: strong ... purpura.
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... mucosal bleeding (Petechial ... or purpuric rash ... SJIA], systemic lupus ... #Diagnosis #Management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... multiforme-like lesions, palpable ... purpura, Pathergy ... (Clinical Dx). ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Henoch Scholein Purpura ... Pathogenesis and Clinical ... and ankles) #HSP ... Pathophysiology #Diagnosis ... #Signs #Symptoms