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diagnosis differential management neurology aids cns hemophagocytic hiv hlh infectiousdiseases iris lymphohistiocytosis reconstitution rheumatology summary syndrome treatment weakness
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... that disrupts immune ... production of pro-inflammatory ... +: Virus (EBV, CMV ... , HHV8,...), Bacteria
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Most CNS opportunistic ... • CNS opportunistic ... required until immune ... - Generally >3 cm ... and <25% culture positive
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Immune Reconstitution ... Inflammatory Syndrome ... with exaggerated inflammatory ... , bacterial superinfection ... keratitis, iritis • CMV
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Vasculitis • Infectious ... Polymyositis • Immune ... Coxsackie, HIV, CMV ... , EBV - Bacterial ... Up: • Chem: CPK
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