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Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
phase Phase 0: Depolarization ... Phase 1: Early repolarization ... phase Phase 3: Repolarization ... Myocytes #Phases #Depolarization ... #Repolarization
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Phase I - Initial Repolarization ... - Ventricular Repolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Differential Diagnosis for ST Segment Elevations - ACUTE STEMI - PULMONARY EMBOLISM - LBBB
EMBOLISM - LBBB (PACEMAKER ... - BENIGN EARLY REPOLARIZATION
Temporary / External Pacing • Transvenous & epicardial pacing are temporary methods of supporting brady- &
permanent implanted pacemaker ... required to trigger depolarization ... to identify a depolarization ... MD @nickmmark #pacemaker ... cardiology #diagnosis #management
Action Potential: Depolarization and repolarization of a neuron #ActionPotential #Depolarization #Repolarization #Neuron #Neurology #Pathophysiology
Action Potential: Depolarization ... and repolarization ... ActionPotential #Depolarization ... #Repolarization
Pacemaker Operating Modes 1 - Chamber paced A (atrium), V (ventricle), D (dual/both) 2
Pacemaker Operating ... period of time the pacemaker ... would trigger pacemaker-mediated ... The voltage the pacemaker ... settings #cardiology #management
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
and magnitude of depolarization ... phase 4 to slow depolarization ... prolong AV node repolarization ... interval (delays time repolarization ... prolong AV node repolarization
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
for the rapid depolarization ... • Slows depolarization ... involved in phase 3 repolarization ... • Prolongs repolarization
Pacemaker Complications • Implantation-Related: Pocket hematoma, Infection (pocket), Pneumothorax, Hemothorax, Lead dislodgement, Cardiac perforation / tamponade
Pacemaker Complications ... cardiomyopathy, Pacemaker ... syndrome, Pacemaker-mediated ... /EricsMedi #Pacemaker ... complications #cardiology #management
Major electrocardiogram findings induced by left ventricular hypertrophy (LVH) An increase in left ventricular mass augments the
alteration in repolarization ... in left atrial depolarization
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