7 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... cases: INR/PT, aPTT ... Diagnosis #Causes #Workup ... #hematology
4T Score for Heparin-Induced Thrombocytopenia

Interpretation of the 4T score:
0-3 points:  Low probability (<<1%)
  -
Heparin-Induced Thrombocytopenia ... - No further workup ... Consider therapeutic anticoagulation ... HeparinInduced #Thrombocytopenia ... Diagnosis #Criteria #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Schistocytes, thrombocytopenia ... Diagnosis #Algorithm #workup ... #hematology #testing
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
platelet, PT, PTT ... Gplb receptor • Thrombcytopenia ... considered first-line testing ... Platelet #disorders #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
for Thrombotic Thrombocytopenic ... performed PT, PTT ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Effect of Direct Oral Anticoagulants on Hemostatic Tests
Horizontal bars correspond to the approximate range of detectability
#doac #noac #anticoagulation ... #hematology #laboratory ... #testing #aptt
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... platelet count (thrombocytopenia ... IDUS) • Immune Thrombocytopenia ... Workup: • Complete ... Treatment: Goals: Treating