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diagnosis management disease cppd adultonset approach calcium comparison deposition dermatology differential fungal hematology infections infectiousdiseases laboratory mds msk mycoses myelodysplasia
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
rheumatic fever • Chronic ... , gout or pseudogout ... hepatitis, herpes • Chronic ... #rheumatology # ... approach #workup
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Must rule out other ... low ferritin, arthritis ... and chronic synovitis ... (40%) Treatment ... #rheumatology #
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
swelling in weird joints ... disease states Pathophysiology ... Chronic CPP Crystal ... Inflammatory Arthritis ... #Comparison #rheumatology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
deposition in joints ... attacks • Other joints ... frequent attacks • Arthritis ... treatment; consider ... #rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
syndrome is a rare chronic ... nonerosive inflammatory arthritis ... diagnosis • Rule out ... and lower jaw Treatment ... SAPHO #Syndrome #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... synovial fluid • Gout ... urate crystals (gout ... Screening Tests for Chronic ... #laboratory #workup
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... Chronic CPP Crystal ... Resembles RA • Chronic ... Acute Pseudogout: Treatment ... Deposition #Disease #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... platelet count (thrombocytopenia ... Marrow Failure • Chronic ... IDUS) • Immune Thrombocytopenia ... Workup: • Complete
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... 85% • < 50% in chronic ... muscle aches, joint ... Aspergillosis Pathophysiology ... Meningitis, septic arthritis
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