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diagnosis leukemia algorithm approach arthritis lymphocytic mds monoclonal msk myelodysplasia myelodysplastic pain paraproteinemias polycythemia rheumatology syndromes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... bone pain, fever, joint ... #Leukemia #Hematology ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Intussusception, SIB ... #Chronic #Lymphocytic ... Leukemia #diagnosis #workup ... #oncology #hematology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Send for cell count ... that patient had ... #rheumatology # ... approach #workup ... #differential #
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... Better call hematology ... normal/high - Chronic ... you’ll do a good workup ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Lymphoma (HCV) • CLL ... Scleromyxedema (CNS+GI+CVS+joints ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... blood count with differential ... Syndromes #diagnosis #hematology ... #oncology
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