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clinical crypto cryptococcal hemophagocytic hlh lymphohistiocytosis management meningitis mri radiology rheumatology summary t2
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... Unknown cause Treatment ... of emergency, ICU ... #management #treatment
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Standard treatment ... survival by 25% ↑ ICP ... to normalize ICP ... approximately 15% ↑ in rate ... meningitis #T2 #MRI #Brain
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