8 results
TTH48 - Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac
Targeted Temperature Management ... - A Randomized Clinical ... admitted to the ICU ... #CriticalCare #ICU ... VisualAbstract #EBM
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
cut-offs defined in clinical ... in HM • False positives ... BAL GM does not differentiate ... - Frozen ice-pops ... Fungal #Biomarkers #BetaDGlucan
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
(COVID19, CMV/EBV ... immobility • Critical ... Illness Myopathy (ICU ... #Elevated #CK #differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
cut-offs defined in clinical ... >90% (In most clinical ... in BAL does not differentiate ... Penicillium), Frozen ice-pops ... blood products #BetaDGlucan
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... biologics (CMV +++, EBV ... of emergency, ICU ... Lymphohistiocytosis #diagnosis #management
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Viral Infection Clinical ... dehydrogenase • Positive ... - Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... Hodgkin Lymphoma - Clinical ... - Lymphocyte rich ... Immunohistochemical studies (to differentiate ... hematology #oncology #management
Sepsis - Interventions that do / do not improve outcomes
Do:
- Have high index of suspicion and
nurses well, pay ICU ... Enroll patient in a clinical ... Interventions #Management ... Factors #Matter #EBM