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betadglucan biomarkers cns comparison differential fungal galactomannan hemophagocytic hiv hlh infections infectiousdiseases lymphohistiocytosis management opportunistic rheumatology summary treatment
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
- Other positives ... infection (IFI) in hematologic ... cut-offs defined in clinical ... - Frozen ice-pops ... Galactomannan #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... of emergency, ICU
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
Infection in HIV / AIDS ... should be based on clinical ... effect/Edema • EBV ... and <25% culture positive ... #AIDS #opportunistic
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