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betadglucan biomarkers comparison creatine differential elevated fungal galactomannan hemophagocytic hlh kinase lymphohistiocytosis management rhabdomyolysis rheumatology summary treatment
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Levels Acute CK ... (COVID19, CMV/EBV ... immobility • Critical ... Illness Myopathy (ICU ... #differential #diagnosis
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
- Other positives ... infection (IFI) in hematologic ... cut-offs defined in clinical ... - Frozen ice-pops ... Galactomannan #diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Infections+++: Virus (EBV ... biologics (CMV +++, EBV ... of emergency, ICU
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