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pharmacology doac hematology anticoagulant coagulation diagnosis noac cascade dabigatran laboratory oral testing abnormal absorption anatomy bridging causes clearance clot dvt
Effect of Anticoagulants on Coagulation Tests PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Coagulation Tests PT ... / INR, aPTT, Anti-Xa ... Clotting Time Warfarin ... Fondaparinux Rivaroxaban ... Apixaban, Edoxaban
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... dosing and bridging ... #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
Coagulation Cascade - Actions of Anticoagulants • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin • Fondaparinux • Direct
Cascade - Actions of Anticoagulants ... Xa Inhibitors: Rivaroxaban ... , Apixaban, Edoxaban ... K Antagonists: Warfarin ... #anticoagulation
Anticoagulants Common Reversal Agents - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra) - Heparin/LMWH
Anticoagulants Common ... Reversal Agents - Warfarin ... (Praxbind) - Apixaban ... Betrixaban (Bevyxxa), Edoxaban ... (Lixiana), Rivaroxaban
Pharmacokinetic Characteristics and Primary Routes of Clearance of Oral Anticoagulant Agents Warfarin - 100% Hepatic, 0% Renal Apixaban
Clearance of Oral Anticoagulant ... Agents Warfarin ... Hepatic, 0% Renal Apixaban ... Hepatic, 80% Renal Edoxaban ... Hepatic, 50% Renal Rivaroxaban
Anticoagulant Sites of Absorption Apixaban - Primarily proximal small intestine; some gastric absorption Dabigatran - Lower stomach and
of Absorption Apixaban ... and duodenum Edoxaban ... small intestine Rivaroxaban ... gastric absorption Warfarin ... Sites #Absorption #anticoagulation
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin #clot #PT ... #anticoagulant ... #Warfarin #Dabigatran ... thrombin #inhibitor #Apixaban ... #Rivaroxaban #Edoxaban
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early warfarin therapy ... Xa inhibitors - Rivaroxaban ... , apixaban, edoxaban ... heparin - Other anticoagulants ... Causes #diagnosis #differential
Warfarin to DOAC and DOAC to Warfarin Transitions Here are a couple of charts to help
DOACs for easier dosing ... Quick tip: apixaban ... Rivaroxaban is < ... Edoxaban is <2.5 ... Transitioning #Anticoagulation
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... For patients on warfarin ... clearance (calculated using ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban
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