8 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... for VTE - Dr. ... #Anticoagulation ... #Dabigatran #Apixaban ... #Rivaroxaban #Edoxaban
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Clotting Time Warfarin ... Fondaparinux Rivaroxaban ... Apixaban, Edoxaban ... Argatroban Dabigatran ... #Testing #Diagnosis
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Pathophysiology Anticoagulation ... the mainstay of VTE ... (e.g. warfarin) ... LMWH #UFH #DOAC #Dabigatran ... #Apixaban #Rivaroxaban
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
For patients on warfarin ... clearance (calculated using ... of Therapy • Dabigatran ... inhibitor) • Apixaban ... , Edoxaban, Rivaroxaban
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
clot #PT #PTT #diagnosis ... #anticoagulant ... #Warfarin #Dabigatran ... thrombin #inhibitor #Apixaban ... #Rivaroxaban #Edoxaban
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Xa inhibitors - Rivaroxaban ... , apixaban, edoxaban ... heparin - Other anticoagulants ... Prolonged #Causes #diagnosis ... #differential #
Atrial Fibrillation (A-Fib) Summary

Symptoms:
• Palpitations, light-headedness, dizziness, dyspnea, exercise intolerance, chest pain, near-syncope, syncope.

Why?
Cardiac:
	• Valvular heart
thrombin inhibitor (dabigatran ... Xa inhibitors (rivaroxaban ... , apixaban, edoxaban ... Fibrillation #AFib #diagnosis ... #management #cardiology
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Differential Diagnosis ... /MRA • Avoid Warfarin ... suggest prophylactic anticoagulation ... Serial TTE and close ... #management #cardiology