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diagnosis hematology algorithm autoimmune causes chronic classification cll cold extravascular hemeonc hemolysis hodgkins intravascular leukemia lymphocytic lymphoma monoclonal paraproteinemias testing
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Anemia (AIHA) - ... Table Warm AIHA ... hemoglobinuria) • Cold Agglutinin ... Disease Mixed-type ... #Anemia #AIHA #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... - Autoimmune (AIHA ... . primary cold agglutin ... disorders, Mycoplasma ... Extravascular #Causes #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #disease #hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder ... #Anemia #Differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... 5) Symptoms of anemia ... chemotherapy for low-risk disease ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... • Coombs (-) hemolytic ... anemia due to cold ... Hematology #Monoclonal #Differential ... #Diagnosis #Oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... number of sites of disease ... classification #hematology #oncology ... #management
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