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diagnosis hematology management differential deficiency oncology signs algorithm pathophysiology refeeding acute agglutinin allergy antibiotics aplastic ascorbicacid atrophicglossitis b1 b12 cancer
Clinically Important Vitamins and Vitamin Deficiency States Fat-soluble Vitamins: • Vitamin A - Xerophthalmia, night blindness,
• Vitamin E - Haemolytic ... anaemia, ataxia ... Wernicke-Korsakoff syndrome ... diagnosis #signs #symptoms ... #nutrition
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... Haematological: Anaemia ... #riskfactors #symptoms ... #nutrition
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
upper limb) • Nutritional ... Anorexia nervosa Treatment ... Encephalopathy • A prompt treatment ... can improve symptoms ... development of Korsakoff syndrome
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
anemia, PNH, immune ... - Pernicious anemia ... • Tumor lysis syndrome ... polyangiitis • Behçet's syndrome ... associated with any symptoms
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... (Cold-induced symptoms ... of anemia include ... anemia • Cold ... #anemia #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... Nutritional
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
initiation of nutrition ... overload) Other Symptoms ... • Seizures • Hemolysis ... hyperparathyroidism Treatment ... #Nutrition #Differential
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Refeeding Syndrome ... - Little or no nutritional ... -DPG -> - hemolysis ... - anemia ... pathophysiology #symptoms
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... Treatment: ... • Improve the symptoms
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
breath, wasting, anemia ... Psychiatric symptoms ... Loss of teeth Anemia ... contribute to nonimmune hemolysis ... vasculitis Treatment
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