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management hematology differential infectiousdiseases treatment activation agglutinin anemia autoimmune cdi cdiff clostridioides clostridium cold difficile disease erythematosus fungal gap gastroenterology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... cytokines, such as IL-1 ... nervous system (CNS ... #Diagnosis #Management ... #Hematology #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Antibodies: 1. ... Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... hemolytic #anemia #hematology ... #diagnosis
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook Clinical Presentation + Progression:
of hospitalized pts ... Epidemiology: • #1 ... A/P: Assess complications ... 10 mg/kg IV x 1 ... Fecal Microbiota Transplant
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... diffusion-perfusion defect (Type 1) ... echocardiography - Assess ... take months after transplant ... hepatopulmonary #syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... • ANA titers > 1: ... Ro/La, anti-Jo-1, ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Epidemiology: • F > M: 9:1 ... Diagnosis: • Dry ... Antinuclear antibodies ≥ 1: ... #Rheumatology # ... Diagnosis #Management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... SPEP can: 1. ... Determine its size ... SPEP cannot: 1. ... #differential #diagnosis
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
RP-ILD), dermato-rheumatologic ... Ab • Anti-Jo-1 ... aspiration > 50% of pts ... enzymes • Anti-Jo-1 ... Myositis #Myopathy #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... clinical forms: 1) ... especially the CNS ... MC: CNS CSF: • ... Hematopoietic stem cell transplant
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