8 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Normal Complement: IgA ... nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... #Vasculitis #differential ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
(GPA) Skin involvement ... surfaces of the joints ... reticularis Differential ... • EGPAHenoch-Schönlein ... #GPA #dermatology
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
Schonlein Purpura ... (HSP, IgA Vasculitis ... #Henoch #Schonlein ... #HSP #IgA #Vasculitis ... #dermatology #skin
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Henoch Schönlein ... Sarcoidosis • GPA ... #joint #pain #skin ... #rashes #differential ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
• Microscopic Polyangiitis ... often present • Henoch ... Schonlein Purpura ... (IgA vasculitis ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... MPO > PR3 60/ GPA ... Schonlein Purpura ... (IgA Vasculitis ... purpura, joint
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Glomerulonephritis ... polyangiitis ... • IgA vasculitis ... (Henoch-Schönlein ... classification #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Schonlein Purpura ... RA, Sjogren's, GPA ... cryoglobulins • Skin ... #Causes #dermatology ... #physicalexam