5 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Normal Complement: IgA ... nephropathy, Henoch-SchonIein ... Purpura Anti-GBM ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Petechiae, Palpable purpura ... Petechiae • Palpable purpura ... Vesicles overlying purpuric ... • EGPA • Henoch-Schönlein ... purpura • Mixed
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... triad of Palpable purpura ... (Henoch-Schönlein ... purpura) • Cutaneous ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... scleritis • Palpable purpura ... Schonlein Purpura ... purpura, joint ... macules, palpable purpura
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis: • Purpura ... Schonlein Purpura ... erythematous nodules, purpura ... scleritis • Palpable purpura ... causing palpable purpura