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Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Findings: • Petechiae ... , Palpable purpura ... sensation or pain: • Petechiae ... • Palpable purpura ... • EGPA • Henoch-Schönlein
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Infection - Vasculitis ... Schonlein Purpura ... Rash: - Purpura ... #Algorithm #Causes
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... purpura, Arthralgia ... • IgA vasculitis ... (Henoch-Schönlein ... purpura) • Cutaneous
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: • Purpura, ischemic ... Schonlein Purpura ... (IgA Vasculitis ... skin) • Palpable ... ) • Palpable purpura
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: • Purpura, ischemic ... Schonlein Purpura ... (IgA vasculitis ... Vasculitis - Skin ... purpura.