834 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
pattern: - SLE, SSc ... SjS, SLE, DM, SSc ... , PM/SSc OS, MCTD ... , PBC/SSc OS ... differential #diagnosis #rheumatology
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
pattern: • SLE, SSc ... SjS, SLE, DM, SSc ... , PM/SSc OS, MCTD ... , PBC/SSc OS • ... differential #diagnosis #rheumatology
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... ) and Anti-La (SSB ... ), Anti-La (SSB) ... Systemic Sclerosis, SSc ... Autoantibodies #Rheumatology
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Sjogren's Syndrome (SS ... or scleroderma (SSc ... ANA #patterns #rheumatology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
of Scleroderma (SSc ... renal crisis (SRC ... #Scleroderma #SSc ... #rheumatology #
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SSc: systemic sclerosis ... Table #Pulmonary #Rheumatology
Scleroderma Associated Telangiectasia. 

If you see them-round, often well circumscribed (but can be matte-like too) &
CTD especially SSc ... #dermatology #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
/AMA: • PBC, SSc ... , PBC/SSc OS, PBC ... differential #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
lupus (90%) Anti-SSA ... 30-40% Target: SS-A ... Sjogren Anti-SSB ... Associated with SLE-SSc-AlM ... erythematosus #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Sjogren's Syndrome (SS ... or scleroderma (SSc ... ANA #patterns #rheumatology