22 results
CLINICAL MANIFESTATIONS 
OF ADRENAL INSUFFICIENCY. 

Primary and secondary adrenal insufficiency:
 - Tiredness, weakness, mental depression
CLINICAL MANIFESTATIONS ... hypotension - Nausea ... mild normocytic anemia ... disorders: - Pale skin ... Insufficiency #Signs
Bullous Pemphigoid - Diagnosis and Management Summary
Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Summary Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... - Erosions and crusts ... #dermatology
Rheumatoid arthritis (RA): Extra-articular manifestations
Skin: 
 • Inflammation of skin (esp. over areas of stress) forms
manifestations Skin ... reticularis Blood: Anemia ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Diagnosis and Management ... extrapulmonary cases ... Clinical Signs ... years - May have signs ... decreased reflexes Pathophysiology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Clinical Presentation ... Headaches • Pale skin ... and petechiae Causes ... • Improve the symptoms ... #diagnosis #management
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... integrity of: • Skin ... poor nutrition Clinical ... Psychiatric symptoms ... , or any other cause
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... TLS #diagnosis #management ... #hematology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... renal failure Clinical ... are not caused ... nodes: 13-15%, skin ... #Signs #Symptoms
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... intrinsic factor, IF) Clinical ... , yellow skin, cognitive ... palpitations), skin ... Deficiency #diagnosis #management
Cullen's sign. Lipase 1,781. Bruising in the skin around the umbilicus. This sign is named after
Bruising in the skin ... conditions that cause ... Pathophysiology: ... pregnancy, or other causes ... onset of other symptoms