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diagnosis hematology differential oncology causes systemic algorithm generalized lymphocytic pruritus comparison cvid erythematosus gap globulin hemeonc hypogammaglobulinemia immunodeficiency immunology lupus
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... - infiltrates (anemia ... bone marrow and secondary ... -> Invade Skin: ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... : • Most common ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #Chronic #Lymphocytic
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... hemorrhage) • Chronic ... myeloid leukemia ... (CML) - Dr. ... #secondary
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... Overview: • Most common ... 5) Symptoms of anemia ... #diagnosis #management
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Creatinine & BUN: • Chronic ... renal failure/uremia ... • Lymphoma • Leukemia ... Pruritus #primary #secondary ... #generalized #dermatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
Systemic Fibrosis: - Secondary ... frequent in men Chronic ... - Occurs most commonly ... hematopoietic stem cell ... comparison #table #dermatology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... Creatinine & BUN: • Chronic ... • Lymphoma • Leukemia ... #Pruritus #secondary ... #generalized #dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Most common cytopenia ... DDX: Rule Out Secondary ... Marrow Failure • Chronic ... Myelogenous Leukemia
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... to impaired B-cell ... Autoimmunity • Chronic ... autoimmune hemolytic anemia ... Malignancies • Chronic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... lymphopenia, low PLT • Anemia ... Kidney disease common ... with Lupus: • Chronic ... Hodgkin lymphoma and leukemia
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