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hematology diagnosis management blood product anemia chemotherapy chronic cll cyp3a4 doac inducers inhibitors interactions leukemia lymphocytic mds myelodysplasia myelodysplastic pglycoprotein
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Headaches • Pale skin ... #Anemia #oncology ... #hematology #diagnosis
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion Reactions ... common immune reaction ... due to marrow aplasia ... infections with skin ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
common immune reaction ... due to marrow aplasia ... infections with skin ... diagnosis #management #hematology ... #reactions
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Pure red cell aplasia ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Causes • Anemia • Aplastic ... Syndromes #diagnosis #hematology ... #oncology
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