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diagnosis hematology differential oncology causes algorithm generalized management pruritus systemic anemia aplastic chronic cll cryofibrinogenemia cutaneous gap globulin lymphocytic mds
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Differential Diagnosis Secondary ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology ... #secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
• Xerosis (dry skin ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... Pruritus #primary #secondary ... #generalized #dermatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... bone marrow and secondary ... CLL -> Invade Skin ... #Hematology #Oncology
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Involving the Skin ... Leukocytoclastic Vasculitis Secondary ... Vasculitis Skin ... Disease • Cogan syndrome ... #dermatology #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... Hepatomegaly • Skin ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... leakage of RBC's secondary ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Vascular reactivity (Skin ... Antiphospholipid syndrome ... Warfarin-induced skin ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary Skin ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #Pruritus #secondary ... #generalized #dermatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... Constitutional Syndromes ... virus (EBV) • Leukemia ... Anemia #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... DDX: Rule Out Secondary ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... #diagnosis #hematology
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