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diagnosis hematology oncology differential leukemia algorithm anemia aplastic atlas cancer chronic cryofibrinogenemia dermatologic disorders gpa granulomatosis history key lymphocytic management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... develop leukostasis syndrome ... • Tumor lysis syndrome ... -> Invade Skin: ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Lymphocytosis: Absolute blood ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... workup #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
work properly, leading ... unusual bruising or bleeding ... just beneath the skin ... are caused by bleeding ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... Liver diseases, Bleeding ... Hemolytic uremic syndrome ... #differential #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... • Goodpasture syndrome ... • Giant cell arteritis ... vasculitis (inflamed blood ... rash #diagnosis #rheumatology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
large numbers of stellate ... hematopoietic stem cell ... be seen after blood ... Differential #Diagnosis #comparison ... #table #dermatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
which can plug blood ... Paradoxical spontaneous bleeding ... Antiphospholipid syndrome ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... ecchymoses, mucosal bleeding ... result from low blood ... Anemia #oncology #hematology
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
in Evaluating Bleeding ... relatives (if all ... and skin haemorrhage ... Marfan syndrome, ... pediatrics #diagnosis #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic syndromes ... From Blood Cancer ... Myelodysplastic syndromes ... an infection or bleeding ... #algorithm #hematology
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