7 results
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Inhibitors (VIII is ... promyelocytic leukemia ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• 75% of ALL is ... develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
incompetent • CLL is ... Hepatomegaly • Skin ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... Headaches • Pale skin ... virus (EBV) • Leukemia ... of CD34+ cells is ... Anemia #oncology #hematology
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Bernard-Soulier Syndrome ... to a lack of GP Ib ... Platelet #Defects #comparison ... #table #differential ... #diagnosis #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... or platelets - is ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
gammopathy, and skin ... changes (POEMS syndrome ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... differential #diagnosis #hematology